NFX

Overview

NFX is a venture capital firm based in San Francisco that invests in pre-seed and seed-stage startups, primarily in technology sectors such as biotech, fintech, marketplaces, and deeptech. It manages over $1.5B in assets across multiple funds and operates internationally in the U.S., Israel, Latin America, and Europe, with a focus on founding teams and market opportunities.¹²⁴

History

NFX was founded in 2015 by serial entrepreneurs who have built and exited companies totaling over $10B in value. The firm has raised multiple funds, including NFX Capital Fund IV closed in October 2025 and NFX SL Advantage I opened in March 2026, with a total of six closed funds.¹⁴ It established initiatives like NFX Guild, a startup accelerator providing mentorship and seed funding, and NFX Bio for scientist-founders in techbio.³⁵

Notable Products

• NFX Capital Fund IV - Venture capital fund closed in October 2025, focused on seed-stage tech investments.
• NFX SL Advantage I - Fund in market since March 2026, targeting early-stage opportunities.
• NFX Guild - Three-month accelerator program offering mentorship, resources, and seed funding for early-stage tech startups.
• NFX Bio - Investment initiative supporting scientist-founders in biology and techbio companies.
• Signal - Founder-VC networking platform used for investment inquiries.

Reputation

NFX is recognized among startup founders and professionals for its operator-led approach, drawing from founders' experience in scaling billion-dollar exits, and its targeted support for pre-seed and seed stages in high-growth tech sectors. It receives positive feedback for international reach and specialized programs like NFX Guild and NFX Bio, though some note its relatively recent entry into VC compared to established firms.²³⁴⁵